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N183

Sigma-Aldrich

NBQX disodium salt hydrate

≥98% (HPLC)

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Synonym(s):
1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate, FG 9202 disodium salt hydrate
Empirical Formula (Hill Notation):
C12H6N4Na2O6S · xH2O
CAS Number:
Molecular Weight:
380.24 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

lyophilized powder

storage condition

desiccated

color

, brown to dark red-brown

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

O.[Na+].[Na+].NS(=O)(=O)c1cccc2c1c(cc3nc([O-])c([O-])nc23)[N+]([O-])=O

InChI

1S/C12H8N4O6S.2Na.H2O/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;;1H2/q;2*+1;/p-2

InChI key

LQSCHRKYVVVUFA-UHFFFAOYSA-L

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This Item
C239N171P1999
vibrant-m

N183

NBQX disodium salt hydrate

vibrant-m

C239

CNQX disodium salt hydrate

vibrant-m

N171

NBQX hydrate

vibrant-m

P1999

PEAQX tetrasodium hydrate

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

lyophilized powder

form

solid

form

powder

form

powder

color

, brown to dark red-brown

color

orange to red

color

yellow

color

white to beige

storage condition

desiccated

storage condition

protect from light

storage condition

-

storage condition

desiccated

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

−20°C

Application

NBQX disodium salt hydrate has been used:
  • in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
  • as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
  • in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)

Biochem/physiol Actions

NBQX disodium salt hydrate is a neuroprotective AMPA/kainate glutamate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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