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O1136

Sigma-Aldrich

Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse

clone ODC-29, ascites fluid

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Synonym(s):
Ornithine Decarboxylase Antibody, Ornithine Decarboxylase Antibody - Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse
MDL number:
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

ODC-29, monoclonal

mol wt

antigen 53 kDa

contains

15 mM sodium azide

species reactivity

human, mouse

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:100

isotype

IgG2b

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ODC1(4953)
mouse ... Odc1(18263)

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D8168I2018P3088
Gene Information

human ... ODC1(4953)
mouse ... Odc1(18263)

Gene Information

human ... DMD(1756)
mouse ... Dmd(13405)
rat ... Dmd(24907)

Gene Information

human ... INS(3630)

Gene Information

human ... PVALB(5816)
rat ... Pvalb(25269)

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

ODC-29, monoclonal

clone

MANDYS8, monoclonal

clone

K36AC10, monoclonal

clone

PARV-19, monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

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General description

Monoclonal Anti-Ornithine Decarboxylase (ODC) (mouse IgG2b isotype) is derived from the ODC-29 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Its amino acid sequence is well conserved among species; the overall identity of the amino acid sequences of mouse, rat and human ODC proteins is greater than 90%.
Ornithine decarboxylase (ODC) levels increase rapidly after implantation during mouse embryogenesis. The gene encoding this protein is localized on mouse chromosome 12 and human chromosome 2.

Specificity

By immunohistochemical staining of formalin-fixed, paraffin-embedded human prostate and colon carcinoma, the labeling is confined to epithelial cells.

Immunogen

recombinant mouse ornithine decarboxylase.

Application

Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse has been used in Western blotting.
Monoclonal Anti-Ornithine Decarboxylase (ODC) has also been used in enzyme linked immunosorbent assay (ELISA), immunoprecipitation, immunoblotting and immunohistochemistry.

Biochem/physiol Actions

Ornithine Decarboxylase (ODC) biological activity is rapidly induced to promote cell proliferation in response to hormones, drugs, growth factors, mitogens and tumour promoters. ODC mRNA levels are also elevated in transformed cells including lung carcinomas and human colon adenomas and carcinomas. ODC activity in colorectal carcinomas has been shown to be greater than that in adenomas, which, in turn, is greater than that of normal mucosa. ODC has a half-life of 8-30 min, the shortest half-life time reported in eukaryotic cells.
Ornithine decarboxylase (ODC) converts L-ornithine to putrescine. It has a role in cell replication. ODC is also involved in the polyamine synthesis pathway. The protein is upregulated in cancers. Overexpression of ODC has been associated with carcinogenesis in mice.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Ornithine Decarboxylase (ODC) Expression Pattern in Human Prostate Tissues and ODC Transgenic Mice
Lei Young
The Journal of Histochemistry and Cytochemistry, 54(2) (2006)
The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth
David Bernard
Oncogene, 25, 1358?1366-1358?1366 (2006)
Myc confers androgen-independent prostate cancer cell growth
David Bernard
The Journal of Clinical Investigation, 112(11), 1724?1731-1724?1731 (2003)
Elevated Epidermal Ornithine Decarboxylase Activity Suppresses Contact Hypersensitivity1
Martin P. Keough
The Journal of Investigative Dermatology, 131(1), 158-166 (2011)
Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene
Noreen J
Gene, 93(2), 257-263 (1990)

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