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P3932

Sigma-Aldrich

Poly(2-hydroxyethyl methacrylate)

BioReagent, powder, suitable for cell culture

Synonym(s):

Poly(2-HEMA), Poly-HEMA

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About This Item

Linear Formula:
(C6H10O3)n
CAS Number:
25249-16-5
MDL number:
MFCD00084374
UNSPSC Code:
12352207
PubChem Substance ID:
24898472
NACRES:
NA.75

biological source

synthetic (organic)

product line

BioReagent

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

ethanol: 120 mg/mL

density

1.15 g/mL at 25 °C (lit.)

SMILES string

CC(=C)C(=O)OCCO

InChI

1S/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3

InChI key

WOBHKFSMXKNTIM-UHFFFAOYSA-N

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Application

Poly(2-hydroxyethyl methacrylate) has been used:
  • as a nonadhesive substrate in the preparation of single cell suspensions
  • to implant into mice cornea for corneal micropocket assay
  • to coat the well plates for sphere assay using adipose-derived mesenchymal stem cells

Biochem/physiol Actions

Poly(2-hydroxyethyl methacrylate) is an acrylic compound and has dental usage. It is mainly used to inhibit cell adhesion to growth surfaces in culture vessels.

Physical form

Water-swellable polymer. Hydrogel.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Manuele Giuseppe Muraro et al.
Stem cells translational medicine, 1(8), 592-603 (2012-12-01)
Increasing evidence that cancers originate from small populations of so-called cancer stem cells (CSCs), capable of surviving conventional chemotherapies and regenerating the original tumor, urges the development of novel CSC-targeted treatments. Screening of new anticancer compounds is conventionally conducted on
Handbook of Occupational Dermatology, 564-564 (2013)
Mohamed Amin et al.
Cell transplantation, 27(2), 285-298 (2018-04-12)
Multilineage-differentiating stress-enduring (Muse) cells are endogenous nontumorigenic stem cells collectable as stage-specific embryonic antigen 3 (SSEA-3) + from various organs including the bone marrow and are pluripotent-like. The potential of human bone marrow-derived Muse cells to commit to cardiac lineage
Gamze Varan et al.
Nanomaterials (Basel, Switzerland), 8(2) (2018-01-27)
Amphiphilic cyclodextrins are biocompatible oligosaccharides that can be used for drug delivery especially for the delivery of drugs with solubility problems thanks to their unique molecular structures. In this paper, Paclitaxel was used as a model anticancer drug to determine
Dario Barbone et al.
PloS one, 11(3), e0150044-e0150044 (2016-03-18)
To investigate the underlying causes of chemoresistance in malignant pleural mesothelioma, we have studied mesothelioma cell lines as 3D spheroids, which acquire increased chemoresistance compared to 2D monolayers. We asked whether the gene expression of 3D spheroids would reveal mechanisms
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