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P4497

Sigma-Aldrich

Anti-Potassium Channel Kv1.3 (extracellular) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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Synonym(s):
Anti-Voltage-gated Potassium Channel KV1.3
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, rat

technique(s)

flow cytometry: 0.5-5 μg
western blot: 1:200-1:500 using rat brain membranes and human Jurkat T lymphocytes.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)

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This Item
P5372P9107K4639
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

antibody form

affinity isolated antibody

Gene Information

human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)

Gene Information

human ... KCNQ1(3784)
mouse ... Kcnq1(16535)
rat ... Kcnq1(84020)

Gene Information

human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)

Gene Information

mouse ... Kcna7(16495)

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

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Immunogen

synthetic peptide corresponding to amino acid residues 211-224 of human KV1.3. The sequence has 12/14 residues identical in rat and mouse.

Physical form

Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Joseph Andronic et al.
Biochimica et biophysica acta, 1828(2), 699-707 (2012-10-09)
Many functions of T lymphocytes are closely related to cell volume homeostasis and regulation, which utilize a complex network of membrane channels for anions and cations. Among the various potassium channels, the voltage-gated K(V)1.3 is well known to contribute greatly
Andreas Schulte-Mecklenbeck et al.
European journal of immunology, 45(9), 2602-2614 (2015-07-04)
Natural killer (NK) cells are a subset of cytotoxic lymphocytes that recognize and kill tumor- and virus-infected cells without prior stimulation. Killing of target cells is a multistep process including adhesion to target cells, formation of an immunological synapse, and
Weiwei Li et al.
Cancers, 14(11) (2022-06-11)
Pancreas ductal adenocarcinoma (PDAC) is one the most aggressive cancers and associated with very high mortality, requiring the development of novel treatments. The mitochondrial voltage-gated potassium channel, Kv1.3 is emerging as an attractive oncologic target but its function in PDAC
Stella A Nicolaou et al.
Journal of immunology (Baltimore, Md. : 1950), 183(10), 6296-6302 (2009-10-21)
The immunological synapse (IS), a highly organized structure that forms at the point of contact between a T cell and an APC, is essential for the proper development of signaling events, including the Ca(2+) response. Kv1.3 channels control Ca(2+) homeostasis

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