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P5295

Sigma-Aldrich

Piracetam

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Synonym(s):
2-(2-Oxopyrrolidino)acetamide, 2-Oxo-1-pyrrolidineacetamide
Empirical Formula (Hill Notation):
C6H10N2O2
CAS Number:
Molecular Weight:
142.16
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

SMILES string

NC(=O)CN1CCCC1=O

InChI

1S/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)

Inchi Key

GMZVRMREEHBGGF-UHFFFAOYSA-N

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Application

Piracetam has been used to study crystal structure and physicochemical properties of six co-crystals of piracetam. It has also been used to study its in vitro antioxidant properties.

Biochem/physiol Actions

Piracetam (2-oxo-1-pyrrolidinyl-acetamide) is a nootropic drug, which enhances memory and facilitates learning. Piracetam also acts as a vasodilator and improves blood flow. It has a potential to treat cognitive impairment in aging, brain injury, memory and balance problems. In addition, piracetam is also used to treat peripheral vascular disease.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Piracetam and vinpocetine ameliorate rotenone-induced Parkinsonism in rats
Zaitone SA, et al.
International Journal of Pharmaceutics, 44(6), 774-774 (2012)
A H Gouliaev et al.
Brain research. Brain research reviews, 19(2), 180-222 (1994-05-01)
Nearly three decades have now passed since the discovery of the piracetam-like nootropics, compounds which exhibit cognition-enhancing properties, but for which no commonly accepted mechanism of action has been established. This review covers clinical, pharmacokinetic, biochemical and behavioural results presented
In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine
Horvath B, et al.
Clinical neuropharmacology, 25(1), 37-42 (2002)
Piracetam co-crystals with OH-group functionalized carboxylic acids
Viertelhaus M, et al.
Crystal Growth & Design, 9(5), 2220-2228 (2009)
Hélène Amieva et al.
PloS one, 8(1), e52755-e52755 (2013-01-18)
Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration.

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