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P6402

Sigma-Aldrich

Perphenazine

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Synonym(s):
4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
Empirical Formula (Hill Notation):
C21H26ClN3OS
CAS Number:
Molecular Weight:
403.97
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

originator

Schering Plough

storage temp.

2-8°C

SMILES string

ClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4

InChI

1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

InChI key

RGCVKNLCSQQDEP-UHFFFAOYSA-N

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1 of 4

This Item
PHR3079P0550000BP422
Perphenazine

P6402

Perphenazine

Perphenazine pharmaceutical secondary standard, certified reference material

PHR3079

Perphenazine

Perphenazine European Pharmacopoeia (EP) Reference Standard

P0550000

Perphenazine

Perphenazine British Pharmacopoeia (BP) Reference Standard

BP422

Perphenazine

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-8°C

originator

Schering Plough

originator

-

originator

-

originator

-

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)

Gene Information

-

Gene Information

human ... DRD2(1813)

Gene Information

human ... DRD2(1813)

General description

Perphenazine is an antipsychotic drug used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drug group in improving response to oxidative injury.

Biochem/physiol Actions

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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Customers Also Viewed

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Donald E Addington et al.
The Journal of clinical psychiatry, 72(1), 75-80 (2010-09-28)
According to the American Psychiatric Association Clinical Practice Guidelines for schizophrenia, second-generation antipsychotics may be specifically indicated for the treatment of depression in schizophrenia. We examined the impact of these medications on symptoms of depression using the data from the
J Nordenberg et al.
Biochemical pharmacology, 58(8), 1229-1236 (1999-09-16)
Some of the psychotropic agents widely used for the amelioration of anxiety, depression, and psychosis also show an effect at the cellular proliferation level. Surprisingly little research, however, has been directed to the antitumoral potential of these drugs, alone or
Alterations in oxidative stress markers and its correlation with clinical findings in schizophrenic patients consuming perphenazine, clozapine and risperidone
Hendouei N, et al.
Biomedicine and Pharmacotherapy, 103, 965-972 (2018)
Frank B Yoon et al.
Statistics in medicine, 30(16), 1917-1932 (2011-05-04)
In clinical trials multiple outcomes are often used to assess treatment interventions. This paper presents an evaluation of likelihood-based methods for jointly testing treatment effects in clinical trials with multiple continuous outcomes. Specifically, we compare the power of joint tests
Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia
Ascher-Svanum H, et al.
BMC Psychiatry, 6(1), 8-8 (2006)

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