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P6744

Sigma-Aldrich

Picric acid solution

1.3% in H2O (saturated)

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Synonym(s):
2,4,6-Trinitrophenol
Linear Formula:
(O2N)3C6H2OH
CAS Number:
Molecular Weight:
229.10
Beilstein:
423400
MDL number:
PubChem Substance ID:
NACRES:
NA.47

form

liquid

Quality Level

concentration

1.3% in H2O (saturated)

color

yellow to very dark yellow

density

1.080 g/cm3

application(s)

hematology
histology

storage temp.

room temp

SMILES string

Oc1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O

InChI

1S/C6H3N3O7/c10-6-4(8(13)14)1-3(7(11)12)2-5(6)9(15)16/h1-2,10H

InChI key

OXNIZHLAWKMVMX-UHFFFAOYSA-N

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This Item
462091.0179916355
Picric acid solution 1.3% in H2O (saturated)

Sigma-Aldrich

P6744

Picric acid solution

Picric acid solution 100 μg/mL in acetonitrile, PESTANAL®, analytical standard

Supelco

46209

Picric acid solution

Nitric acid 69% for analysis EMSURE® ACS,Reag. Ph Eur

Supelco

1.01799

Nitric acid 69%

Nitric acid concentrate 0.1 M HNO3 in water (0.1N), eluent concentrate for IC

Supelco

16355

Nitric acid concentrate

concentration

1.3% in H2O (saturated)

concentration

100 μg/mL in acetonitrile

concentration

-

concentration

0.1 M HNO3 in water (0.1N)

density

1.080 g/cm3

density

-

density

1.41 g/cm3 at 20 °C

density

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

color

yellow to very dark yellow

color

-

color

-

color

-

application(s)

hematology
histology

application(s)

agriculture
cleaning products
cosmetics
food and beverages
personal care

application(s)

-

application(s)

-

General description

Picric acid is a polynitrated aromatic acid. It dissolves in water to form a solution with low pH (pH 2.0). It interacts with basic groups of proteins, forms salts and coagulates them. Fixation with picric acid gives a bright stain, but there might be a loss of nucleic acids due to the low pH of the solution.
Picric acid is anionic and has a low molecular weight.

Application

Picric acid is commonly used as a fixative and staining reagent in forensic and histological applications. It is a general cytoplasmic stain, connective tissue fiber stain, and a fixative for tissues.
  • It is a component of picrosirius red which is used to stain collagen.
  • Bouin’s fluid which also comprises picric acid is a fixative for nuclei and connective tissue.
  • It can be used as a colorimetric reagent in creatinine determination assay.

Supplementary Hazards

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Xin Is a Marker of Skeletal Muscle Damage Severity in Myopathies
The American Journal of Pathology, 183 (2013)
Reexploring picrosirius red: A review
Gopinathan, et al.
Indian Journal of Pathology & Microbiology, 7(2) (2020)
Regulator of G-Protein Signaling-5 Is a Marker of Hepatic Stellate Cells and Expression Mediates Response to Liver Injury
Arya Bahrami
PLoS ONE (2014)
Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
Benjamin Le Calve
Oncotarget (2016)
Histological and histochemical methods: Theory and practice (5th ed.)
JA Kiernan
Histological and Histochemical Methods: Theory and Practice (2015)

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