R2533

RS-127445 hydrochloride

≥98% (HPLC), powder

• Synonym(s): 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₁₆FN₃ · HCl
• CAS Number: 199864-86-3
• Molecular Weight: 317.79
• NACRES: NA.77
• PubChem Substance ID: 329824019
• UNSPSC Code: 12352200
• MDL number: MFCD11112196
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥20 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
• InChI: 1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
• InChI key: MKJPYBJBPRFMHL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist.

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable