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R6267

Sigma-Aldrich

RANTES human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Regulated on Activation, Normal T-cell Expressed and Secreted

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About This Item

EC Number:
200-835-2
MDL number:
MFCD00213042
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

1-5 ng/mL EC50

mol wt

7.8-8.7 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P13501

storage temp.

−20°C

Gene Information

human ... CCL5(6352)

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General description

Regulated on activation, normal T cell expressed and secreted (RANTES), also known as C-C motif chemokine ligand 5 (CCL5), is encoded by the gene mapped to human chromosome 17. RANTES belongs to the chemokine family of proinflammatory basic polypeptides and is expressed by various hematopoietic and non-hematopoietic cell types involved in homing and migration of effector and memory T cells during acute infections.

Biochem/physiol Actions

Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5. RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. A variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV -1 infection.

Physical form

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.

Analysis Note

The biological activity is tested in culture using Baf/3 cells. Chemotaxis: EC50: 1-5 ng/mL

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F

flash_point_c

2 °C

Certificates of Analysis (COA)

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A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection.
Crawford A
PLoS Pathogens (2011)
Role of chemokine and cytokine polymorphisms in the progression of HIV-1 disease.
Biochemical and Biophysical Research Communications (2010)
Frequency of diagnosis of malignant melanoma.
Roth-Moyo L
Canadian Medical Association Journal (1977)
RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase.
Journal of Immunology (1995)
T J Schall et al.
Nature, 347(6294), 669-671 (1990-10-18)
An important process in the immune response is the migration of different populations of lymphocytes at the proper time to sites of antigenic challenge. Although several chemoattractants are known for broad classes of lymphocytes, such as T and B cells
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