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Key Documents

RAB1574

Sigma-Aldrich

Human Matriptase ELISA

for serum, plasma and cell culture supernatants

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.41 ng/mL
standard curve range: 0.410-100 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ST14(6768)

General description

The ST14 (suppression of tumorigenicity 14) gene encodes a cell surface serine protease which is also called as matriptase. The ST14 gene is mapped to human chromosome 11q24.3.
This ELISA antibody pair detects Human Matriptase. Other species not yet determined.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

St14 (suppression of tumorigenicity 14) forms complexes with serine proteases inhibitors HAIs (hepatocyte growth factor activator inhibitors), to prevent its proteolytic activity. ST14 expression is required for epithelial mesenchymal transition in tumor cells. St14′s biological activity is specific to different substrates, which includes extracellular matrix proteins, hepatocyte growth factor, epidermal growth factor receptor (EGFR), adhesion molecules including Mac25 (insulin-like growth factor-binding protein 7) and Tie2 (angiopoietin-1 receptor) , proteases including urokinase plasminogen activator (uPA), prostasin (PRSS8), matrix metalloprotease 3 (MMP3). Upregulation of the gene is found in progressed epithelial cancer but lower expression of the gene is observed in colon cancer and hence it is termed ‘suppression of tumors′.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase.
Basel-Vanagaite L, et al.
American Journal of Human Genetics, 80(3), 467-477 (2007)
Activation of proHGF by St14 induces mouse embryonic stem cell differentiation.
Yan X, et al.
Protein & cell, 7(8), 601-605 (2016)
Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (Prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer.
Kim S, et al.
Oncotarget, 7(23), 34643-34643 (2016)

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