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S0814

Sigma-Aldrich

Anti-phospho-Serotonin N-Acetyltransferase (N-Terminal) (pThr29) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD02265746
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat

technique(s)

western blot: 0.5 μg/mL

UniProt accession no.

Q64666

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr29)

Gene Information

rat ... Aanat(25120)

Immunogen

synthetic phosphopeptide derived from the N-terminal region of rat AA-NAT that contains threonine 29.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Physical form

Solution in phosphate buffered saline, containing 1 mg/ml BSA and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marco A Pires-Lapa et al.
International journal of molecular sciences, 19(8) (2018-07-28)
Melatonin (5-methoxy-N-acetylserotonin), the pineal hormone, is also synthesized by immune-competent cells. The pineal hormone signals darkness, while melatonin synthesized on demand by activated macrophages at any hour of the day acts locally, favoring regulatory/tolerant phenotypes. Activation of β-adrenoceptors in pinealocytes
Marlina O Córdoba-Moreno et al.
Scientific reports, 10(1), 4799-4799 (2020-03-18)
Daily oscillation of the immune system follows the central biological clock outputs control such as melatonin produced by the pineal gland. Despite the literature showing that melatonin is also synthesized by macrophages and T lymphocytes, no information is available regarding
Sandra Marcia Muxel et al.
PloS one, 7(12), e52010-e52010 (2013-01-04)
We demonstrate that during inflammatory responses the nuclear factor kappa B (NF-κB) induces the synthesis of melatonin by macrophages and that macrophage-synthesized melatonin modulates the function of these professional phagocytes in an autocrine manner. Expression of a DsRed2 fluorescent reporter
Claudia Emanuele Carvalho-Sousa et al.
Journal of pineal research, 68(3), e12636-e12636 (2020-02-12)
Environmental pollution in the form of particulate matter <2.5 μm (PM2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response

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