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S1006

Sigma-Aldrich

Sulfatides from bovine brain

≥97% (TLC), powder

Synonym(s):

Cerebroside sulfate

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

product name

Sulfatides from bovine brain,

Quality Level

storage temp.

−20°C

General description

Sulfatideis a glycospingolipid and plays an essential role in host-pathogen recognition,β-cell function, infection, haemostasis/thrombosis, protein trafficking, cellgrowth, cell adhesion, neuronal plasticity, cell morphogenesis, and signaltransduction. It is found on the surface of the blood cells such asplatelets, leukocytes, and erythrocytes. Sulfatides are also found in the serumas glycosphingolipids in lipoproteins. It is made up of glycan part, a hydrophobic part, 3-O-sulfated galactose, and ceramide, which in turn is composed of a sphingosine base and a fatty acid. It is an important component forthe maintenance of the myelin sheath andproper formation of the axo-glial junctions. Variations in the production ofsulfatides are associated with various human diseases like cancer andimmunological disorders. Alterations in the sulfatide metabolism lead to synapticdysfunction, neurological decline, inflammation, and myelin deterioration.
Sulfatide is a 3-O-sulfogalactosylceramide consisting primarily of galacto cerebroside sulfate. It is localized in myelin sheath and comprises approximately 4% of total myelin lipid in brain.

Application

Sulfatides has been used in:
  • enzyme linked immunosorbent assay (ELISA) in human plasma samples
  • thin layer chromatography in myelin membranes
  • in sulfatide binding assay of properdin

Biochem/physiol Actions

Sulfatides play a key role in physiological processes of nervous system, immune system and in insulin secretion. Anomalies in sulfatides catabolism in lysosome is implicated in late infantile metachromatic leukodystrophy. High levels of sulfatides is also observed in ovarian cancer. Sulfatides contribute to the pathogenesis of chronic inflammatory diseases of the central nervous system.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sulfatide-binding assay for von Willebrand factor: detection of von Willebrand's disease without discrimination of vWD subtypes
Favaloro EJ
Thrombosis Research, 98(2), 213-219 (2000)
Quantification of sulfatides and lysosulfatides in tissues and body fluids by liquid chromatography tandem mass spectrometry
Mirzaian M, et al.
Journal of Lipid Research, 56(8), 936-943 (2015)
Maria Blomqvist et al.
Molecular and cellular neurosciences, 116, 103670-103670 (2021-09-26)
Sulfatide (3-O-sulfogalactosylceramide, SM4) is a glycosphingolipid, highly multifunctional and particularly enriched in the myelin sheath of neurons. The role of sulfatide has been implicated in various biological fields such as the nervous system, immune system, host-pathogen recognition and infection, beta
Age-and brain region-specific effects of dietary vitamin K on myelin sulfatides
Crivello NA, et al.
The Journal of Nutritional Biochemistry, 21(11), 1083-1088 (2010)
A recombinant two-module form of human properdin is an inhibitor of the complement alternative pathway
Kouser L, et al.
Molecular Immunology, 73(11), 76-87 (2016)

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