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SAB1307178

Sigma-Aldrich

ANTI-GSDMA(N-TERMINAL) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
GSDM, GSDM1, GSDMA, Gasdermin-1, Gasdermin-A

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

49365 Da

species reactivity

mouse, human

technique(s)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GSDMA(284110)

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This Item
HPA023313G7422SAB4200798
antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

antibody form

purified from hybridoma cell culture

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

GSD-14, monoclonal

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

49365 Da

mol wt

-

mol wt

antigen ~55 kDa

mol wt

~53 kDa

species reactivity

mouse, human

species reactivity

human

species reactivity

human

species reactivity

human

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General description

Gasdermin A (GSDMA) is located at 17q21.1 on the human chromosome. Its molecular weight is 49 kDa. GSDMA is localized in the pit cells of the gastric epithelium.

Biochem/physiol Actions

Gasdermin A (GSDMA) plays a major role in regulating the tumor growth factor- β (TGF-β) and induces apoptosis. Mutation in this gene leads to gastric adenocarcinoma.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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GSDMA (gasdermin A)
Saeki N and Sasaki H
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
Yingwei Zhu et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 653-664 (2021-04-25)
Nonalcoholic steatohepatitis (NASH) is an inflammatory disease with severe outcomes. Hepatocyte death, including apoptosis, necrosis, and pyroptosis, has been implicated in pathophysiology of NASH. Pyroptosis is mediated by inflammasome activation pathways including caspase-1-mediated canonical signaling pathway and caspase-11-mediated noncanonical signaling

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