SAB1409990
Monoclonal Anti-PTTG1 antibody produced in mouse
clone 3H8, purified immunoglobulin, buffered aqueous solution
Synonym(s):
EAP1, HPTTG, MGC126883, MGC138276, PTTG, TUTR1
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About This Item
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3H8, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PTTG1(9232)
General description
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. (provided by RefSeq)
Immunogen
PTTG1 (NP_004210, 93 a.a. ~ 113 a.a) synthetic peptide.
Sequence
MTEKTVKAKSSVPASDDAYPE
Sequence
MTEKTVKAKSSVPASDDAYPE
Physical form
Solution in phosphate buffered saline, pH 7.4
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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