SAB2702266
Monoclonal Anti-Influenza A virus H1N1 HA (Hemagglutinin) antibody produced in mouse
clone GT223, affinity isolated antibody
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UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
GT223, monoclonal
form
buffered aqueous solution
species reactivity
influenza A virus
concentration
1mg/mL
technique(s)
indirect immunofluorescence: suitable
western blot: 500-3000
isotype
IgG1
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Influenza virus hemagglutinin (HA) precursor is encoded by the gene mapped on segment 4. The encoded protein is a 76kDa surface glycoprotein and it exists as trimers on the envelope.
Immunogen
Recombinant fragment corresponding to C-terminal region of Influenza A virus Hemagglutinin (HA) (A/WSN/1933(H1N1)).
Application
Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biochem/physiol Actions
Influenza virus hemagglutinin (HA) acts as a key immunogen in avian influenza virus (AIV) vaccines. Activated HA facilitates virus attachment to oligosaccharide receptors on host cell surface and is involved in penetration through fusion following conformational modifications in the endolysosomal compartment. 226 and 228 residues in HA of the H3 subtype play a key role in host range restriction and receptor specificity.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Other Notes
Purification: Affinity purified by Protein G
Physical form
Phosphate-buffered saline, no preservative added.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction.
Vines A
Journal of Virology (1998)
A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity.
Glaser L
Journal of Virology (2005)
Barbara Szutkowska et al.
International journal of molecular sciences, 23(5) (2022-03-11)
Influenza A virus (IAV) is a member of the single-stranded RNA (ssRNA) family of viruses. The most recent global pandemic caused by the SARS-CoV-2 virus has shown the major threat that RNA viruses can pose to humanity. In comparison, influenza
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