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Anti-NOD3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Anti-CLR16.2, Anti-NLRC3, Anti-Nucleotide-binding oligomerization domain containing 3

biological source


Quality Level



antibody form

affinity isolated antibody

antibody product type

primary antibodies




buffered aqueous solution

species reactivity

rat, mouse, human


immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.


target post-translational modification


Gene Information

human ... NLRC3(197358)

General description

NLR family CARD domain containing 3 (NLRC3), also referred to as nucleotide-binding oligomerization domain containing 3 (NOD3), is encoded by the gene mapped to human chromosome 16p13.3. The encoded protein belongs to the NLR protein family and is abundantly expressed in purified T cells, B cells and natural killer (NK) cells, but also in thymus, uterus and kidney.


NOD3 antibody was raised against an 18 amino acid peptide near the center of human NOD3.

Biochem/physiol Actions

NLR family CARD domain containing 3 (NLRC3) negatively regulates nuclear factor-κB (NF-κB) activity and innate immune signaling induced by the DNA sensor STING (stimulator of interferon gene). NLRC3 inhibits mammalian target of rapamycin (mTOR) pathways involved in providing protection against colorectal cancer. Thus, downregulated expression of the gene has been observed in colorectal cancer and Wegener′s granulomatosis patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.


The action of this antibody can be blocked using blocking peptide SBP3500544.

Physical form

Supplied in PBS with 0.02% sodium azide.

Storage Class

10 - Combustible liquids


Not applicable


Not applicable

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