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Anti-Tenascin antibody, Mouse monoclonal

clone BC-24, purified from hybridoma cell culture

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Anti-Cytotactin, Anti-GMEM, Anti-GP 150-225, Anti-Glioma-associated-extracellular matrix antigen, Anti-Hexabrachion, Anti-JI, Anti-Myotendinous antigen, Anti-Neuronectin, Anti-TN, Anti-Tenascin-C (TN-C)

biological source


Quality Level

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies


BC-24, monoclonal


buffered aqueous solution

species reactivity



~1.0 mg/mL


ELISA: suitable
flow cytometry: suitable
immunoblotting: suitable
immunohistochemistry: 5-10 μg/mL using pronase-retrieved formalin-fixed, paraffin-embedded human tonsil sections



UniProt accession no.

shipped in

dry ice

storage temp.


target post-translational modification


Gene Information

human ... TNC(3371)

Related Categories

General description

Monoclonal Anti-Tenascin (mouse IgG1 isotype) is derived from the BC-24 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with human tenascin. Tenascin-C (TN-C) is also known as Hexabrachion, Cytotactin, Neuronectin (NEC1). It is a high molecular mass extracellular matrix glycoprotein. Human tenascin is a disulfide-linked hexamer composed of 3 subunits of 190, 200, and 220 kDa.


Human tenascin


Anti-Tenascin antibody has been used:
  • in immunoblotting
  • in Immunohistochemistry
  • in flow cytometry
  • in enzyme linked immunosorbent assay(ELISA)
  • for blocking tenascin-C proliferating activity

Biochem/physiol Actions

Tenascin-C (TN-C) functions in cell adhesion, fibroblast migration, and other processes related to tissue remodeling and wound healing. It has been proposed that actively growing, migrating and differentiating epithelial sheets can produce factors such as (Transforming growth factor beta) TGF-β to stimulate tenascin expression. Neo-expression or increased expression of tenascin has been found in the stroma of various tumors and during normal tissue repair. Intracytoplasmic tenascin immunoreactivity has been detected in malignant melanomas and in lung carcinomas, and it serves as a marker of stromal element proliferation in invasive breast carcinomas. High-molecular mass tenascin isoform plays a role in generating a permissive environment for proliferation, invasion, and metastasis of neoplastic epithelial cells. Human tenascin contains an Arg-Gly-Asp (RGD) sequence which may function in cell adhesion and mediates cell attachment through an RGD-dependent integrin receptor.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Other Notes

This product is for R&D use only, not for drug, household, or other uses.

Storage Class

10 - Combustible liquids




Not applicable


Not applicable

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