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Key Documents

SAB4300400

Sigma-Aldrich

Anti-PRKD1 (Ab-910) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-PKC-MU antibody produced in rabbit, Anti-PKCM antibody produced in rabbit, Anti-PKD antibody produced in rabbit, Anti-PRKCM antibody produced in rabbit, Anti-protein kinase D1 antibody produced in rabbit

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About This Item

MDL number:
MFCD03455823
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~115 kDa

species reactivity

human, mouse

concentration

1 mg/mL

Related Categories

General description

PRKD1 gene encodes PKD1 (protein kinase D1), that belongs to the protein kinase D family. It is a serine/threonine kinase, which is expressed in cells of the normal mammary gland. The PRKD1 gene promoter has a great CpG island covering 1.2kb, including the transcription start site and the entire exon 1.

Immunogen

Peptide sequence around aa. 908-912 (R-V-S-I-L), according to the protein PRKD1.

Biochem/physiol Actions

PRKD1 (Protein kinase D 1) is a negative modulator of cell migration . It plays an important role in cell adhesion, cell migration, vesicle transport, cell survival , signal transduction, membrane trafficking and immune function. It preserves the epithelial phenotype by inhibiting epithelial-to-mesenchymal transition.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-kappa-B.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
871521128

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Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis
Borges S, et al.
Breast Cancer Research, 15(2) (2013)
The AR/NCOA1 axis regulates prostate cancer migration by involvement of PRKD1
Luef B, et al.
Endocrine-Related Cancer, 23(6), 495-508 (2016)
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
Weinreb I, et al.
Nature Genetics, 46(11), 1166-1169 (2014)
Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease.
Ay M
Journal of Neurochemistry, 135(2), 402-415 (2015)

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