SAB4300555
Anti-OPRM1 (Ab-375) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-KIAA0403 antibody produced in rabbit, Anti-MOR antibody produced in rabbit, Anti-MOR1 antibody produced in rabbit, Anti-OPRM antibody produced in rabbit, Anti-opioid receptor, mu 1 antibody produced in rabbit
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~80 kDa
species reactivity
mouse, rat
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(H-P-S-T-A)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... OPRM1(4988)
General description
The gene OPRM1 (opioid receptor μ 1) is mapped to human chromosome 6q24-q25. The gene spans a length of 200kb and contains 11 exons that yield 17 splice variants.
Immunogen
Peptide sequence around aa. 373-377 (H-P-S-T-A), according to the protein OPRM1.
Application
Anti-OPRM1 (Ab-375) antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions
The gene OPRM1 (opioid receptor μ 1) encodes a μ opioid receptor that functions in pain perception and addiction to drugs of abuse, such as cocaine, nicotine and alcohol. It serves as a target for opioid drugs, such as morphine, methadone and heroin and opioid peptides (like β - endorphin and endomorphins) and mediates their effects. Single nucleotide polymorphism in the OPRM1 gene is associated with an inclination to drug addiction and lesser response to painful stimuli.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Target description
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Association of time-dependent changes in μ opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving.
Theberge FR, et al.
Psychopharmacology (Psychopharmacologia), 224(4), 559-571 (2012)
Jörn Lötsch et al.
Anesthesiology, 97(4), 814-819 (2002-10-03)
Some, but not all, patients with renal dysfunction suffer from side effects after morphine administration because of accumulation of the active metabolite morphine-6-glucuronide (M6G). The current study aims to identify genetic causes that put patients at risk for, or protect
Raymond F Anton et al.
Archives of general psychiatry, 65(2), 135-144 (2008-02-06)
Naltrexone hydrochloride treatment for alcohol dependence works for some individuals but not for everyone. Asn40Asp, a functional polymorphism of the mu-opioid receptor gene (OPRM1), might predict naltrexone response. To evaluate whether individuals with alcoholism who are heterozygous (Asp40/Asn40) or homozygous
Shinya Kasai et al.
Pharmacogenomics, 12(9), 1305-1320 (2011-09-17)
The µ-opioid receptor is a primary target for clinically important opioid analgesics, including morphine, fentanyl and methadone. Many genetic variations have been identified in the human µ-opioid receptor MOP gene (OPRM1), and their implications have been reported in the effects
Florence R M Theberge et al.
Psychopharmacology, 224(4), 559-571 (2012-07-14)
Responding to heroin cues progressively increases after cessation of heroin self-administration (incubation of heroin craving). We investigated whether this incubation is associated with time-dependent changes in brain-derived neurotrophic factor (BDNF) and methyl-CpG binding protein 2 (MeCP2) signaling and mu opioid
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