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Key Documents

SAB4300592

Sigma-Aldrich

Anti-PXN (Ab-88) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLJ16691 antibody produced in rabbit, Anti-paxillin antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~68 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(P-V-Y-G-S)

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PXN(5829)

General description

PXN (paxillin) is a focal adhesion-associated tyrosine-based protein, that is present in the cytoplasm. It is a 68kDa protein that is located on chromosome 12q24.

Immunogen

Peptide sequence around aa. 86-90 (P-V-Y-G-S), according to the protein PXN.

application

Anti-PXN (Ab-88) antibody has been used in immunofluorescence.

Biochem/physiol Actions

Paxillin (PXN) controls signal transduction, cell morphology and motility, cytoskeletal rearrangements, proliferation and apoptosis. It serves as an oncogene, hence it plays a major role in the growth of human carcinomas.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti
Carlisle FA, et al.
Gene Expression Patterns, 12(5-6), 172-179 (2012)
Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells
Du C, et al.
Oncology Reports, 35(1), 409-417 (2016)
Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients
Zhao CJ, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 21, 1989-1995 (2015)
Expression of paxillin in laryngeal squamous cell carcinoma and its prognostic value
Li L, et al.
International Journal of Clinical and Experimental Pathology, 8(8), 9232-9239 (2015)
The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells
Maier B, et al.
Cell Cycle, 12(9), 1457-1471 (2013)

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