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Key Documents

SAB4500675

Sigma-Aldrich

Anti-MKP1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

3CH134, CL100, DUS1, Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 39 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DUSP1(1843)

General description

Anti-MKP1 Antibody detects endogenous levels of total MKP1 protein.

MKP1 (mitogen-activated protein kinase phosphatase 1)/DUSP1 (dual specificity phosphatase 1) is a dual specificity phosphatase. It is also called as CL100, 3CH134 and Erp. MKP1 is located in the nucleus and is expressed in several tissues. It is located on human chromosome 5q35.

Immunogen

The antiserum was produced against synthesized peptide derived from human MKP1.

Immunogen Range: 318-367

Biochem/physiol Actions

In mast cells, MKP1 (mitogen-activated protein kinase phosphatase 1) blocks the functions of extracellular signal-regulated kinase (Erk)‐1/2 by glucocorticoid. It controls axon branching promoted by BDNF (brain-derived neurotrophic factor).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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MAP kinase phosphatases
Theodosiou A and Ashworth A
Genome Biology, 3(7) (2002)
Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1
Kassel O, et al.
The Embo Journal, 20(24), 7108-7116 (2001)
Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells
Franklin CC and Kraft AS
The Journal of Biological Chemistry, 272(27), 272(27)-272(27) (1997)
Y Chu et al.
The Journal of biological chemistry, 271(11), 6497-6501 (1996-03-15)
Mitogen-activated protein (MAP) kinases can be grouped into three structural families, ERK, JNK, and p38, which are thought to carry out unique functions within cells. We demonstrate that ERK, JNK, and p38 are activated by distinct combinations of stimuli in
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching
Jeanneteau F, et al.
Nature Neuroscience, 13(11), 1373-1379 (2010)

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