SAB4500989
Anti-FOLR1 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
FR-α, Folate receptor, Folate receptor α, Folate receptor 1, adult
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 29 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FOLR1(2348)
General description
The folate receptor 1 (FOLR1) gene encodes for folate receptor α protein, a membrane-bound glycoprotein. The FOLR1 gene is mapped on the human chromosome at 11q13.4. Anti-FOLR1 antibody detects endogenous levels of total FOLR1 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human FOLR1.
Immunogen Range: 41-90
Immunogen Range: 41-90
Biochem/physiol Actions
Folate receptor α protein binds and facilitates the transport of folate into the cells. This protein acts as a therapeutic target as well as a prognostic marker for various kinds of cancers. Upregulation of the FOLR1 gene is associated with ovarian, lung, breast, brain, colorectal, and gastric cancers.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Minsung Kim et al.
PloS one, 13(6), e0198347-e0198347 (2018-06-07)
Gastric cancer is a malignancy that has a high mortality rate. Although progress has been made in the treatment of gastric cancer, many patients experience cancer recurrence and metastasis. Folate receptor 1 (FOLR1) is overexpressed on the cell surface in
Michelle R O'Byrne et al.
Birth defects research. Part A, Clinical and molecular teratology, 88(8), 689-694 (2010-08-05)
Meningomyelocele (MM) results from lack of closure of the neural tube during embryologic development. Periconceptional folic acid supplementation is a modifier of MM risk in humans, leading toan interest in the folate transport genes as potential candidates for association to
Yuan Yuan et al.
Human pathology, 40(10), 1453-1460 (2009-05-21)
The objective of this study was to analyze the diagnostic and clinical role of the folate receptor-alpha (FOLR1) and folate receptor-gamma (FOLR3) genes in effusion cytology. Expression of the FOLR1 protein product, FR-alpha, was additionally studied. Ninety-one effusions (71 ovarian
Correction: Folate receptor-α (FOLR1) expression and function in triple negative tumors.
Brian M Necela et al.
PloS one, 10(4), e0127133-e0127133 (2015-05-01)
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