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SAB4501477

Sigma-Aldrich

Anti-5-HT-2C antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 2C, Serotonin receptor 2C
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 51 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HTR2C(3358)

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This Item
SAB4501478SAB4501474SAB4501475
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

mol wt

antigen 51 kDa

mol wt

antigen 51 kDa

mol wt

antigen 52 kDa

mol wt

antigen 54 kDa

technique(s)

ELISA: 1:5000, immunohistochemistry: 1:50-1:100, immunofluorescence: 1:100-1:500

technique(s)

ELISA: 1:40000, western blot: 1:500-1:1000

technique(s)

ELISA: 1:5000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100

technique(s)

ELISA: 1:1000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

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General description

5-HT-2C/HTR2C (5-hydroxytryptamine receptor 2C) receptor is a seven transmembrane domain protein. It is located on human chromosome Xq22-23.
Anti-5-HT-2C antibody detects endogenous levels of total 5-HT-2C protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human 5-HT-2C.

Immunogen Range: 161-210

Biochem/physiol Actions

In the nervous system, 5-HT-2C/HTR2C (5-hydroxytryptamine receptor 2C) participates in coordinating the intracellular responses to serotonin. It plays a major role in the modulation of energy homeostasis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Gene structure and expression of serotonin receptor HTR2C in hypothalamic samples from infanticidal and control sows
Quilter CR, et al.
BMC Neuroscience (2012)
Rajat K Das et al.
Respiratory physiology & neurobiology, 260, 105-113 (2018-11-18)
Hypoglossal (XII) motoneurons are activated by type 2 receptors for serotonin (5-HT). This activation is especially strong during wakefulness which facilitates diverse motor functions of the tongue, including the maintenance of upper airway patency in obstructive sleep apnea (OSA) patients.
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
Xu Y, et al.
Neuron, 60(4), 582-589 (2008)

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