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Key Documents

SAB4502077

Sigma-Aldrich

Anti-Parkin antibody produced in rabbit

affinity isolated antibody

Synonym(s):

PARK2, PRKN, PRKN2, Parkinson disease protein 2, Parkinson juvenile disease protein 2

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 51 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PARK2(5071)

General description

Anti-Parkin Antibody detects endogenous levels of total Parkin protein.
Parkin RBR E3 ubiquitin protein ligase (PARK2) is a putative tumor suppressor gene. It possesses an amino-terminal region containing the Ubl (ubiquitin like) domain and a carboxy-terminal region with four zinc coordinating domains. Parkin is a 465 amino acid protein, which is part of the ubiquitin-proteasome system that targets proteins for degradation. The gene encoding it is localized on human chromosome 6q25.2-q27.

Immunogen

The antiserum was produced against synthesized peptide derived from human Parkin.

Immunogen Range: 1-50

Application

Anti-Parkin antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

The expression of parkin RBR E3 ubiquitin protein ligase (PARK2) has been found to be altered in various malignancies. Parkin has a neuroprotective E3 ligase activity and polyubiquitylates proteins before degradation. Mutations in the gene encoding it have been linked to autosomal recessive juvenile parkinson (ARJP) disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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PARK2 polymorphisms predict disease progression in patients infected with hepatitis C virus
Al-Qahtani AA, et al.
Annals of Hepatology, 15(6), 824-833 (2017)
Genetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients
Naseem A, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(6), 1010428317703635-1010428317703635 (2017)
High tidal volume induces mitochondria damage and releases mitochondrial DNA to aggravate the ventilator-induced lung injury
Lin J, et al.
Frontiers in Immunology, 9(6), 1477-1477 (2018)
A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein.
Biswas R and Bagchi A
Gene, 610, 49-58 (2017)
Jin-Yuan Lin et al.
Frontiers in immunology, 9, 1477-1477 (2018-07-19)
This study aimed to determine whether high tidal volume (HTV) induce mitochondria damage and mitophagy, contributing to the release of mitochondrial DNA (mtDNA). Another aim of the present study was to investigate the role and mechanism of mtDNA in ventilator-induced

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