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SAB4502954

Sigma-Aldrich

Anti-TGF β1 antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
CED, DPD1, TGF-β 1, diaphyseal dysplasia 1, progressive
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

application(s)

research pathology

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TGFB1(7040)

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This Item
SAB5700772T0688SAB4502958
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

unconjugated

UniProt accession no.

P01137

UniProt accession no.

P01137

UniProt accession no.

P01137

UniProt accession no.

P36897

mol wt

antigen 44 kDa

mol wt

44

mol wt

-

mol wt

antigen 55 kDa

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General description

Anti-TGF β1 Antibody detects endogenous levels of total TGF β1 protein.
The TGF β1 (transforming growth factor β1) gene is mapped to human chromosome 19q13.2.

Immunogen

The antiserum was produced against synthesized peptide derived from human TGF beta1.

Immunogen Range: 336-385

Application

Anti-TGF β1, C-Terminal antibody produced in rabbit has been used in immunohistochemistry and Western blot analysis.

Biochem/physiol Actions

TGF β1 (transforming growth factor β1) mediates cell vitality, proliferation, epithelial–mesenchymal transition and promotes angiogenesis. TGF β1 controls the process of apoptosis, organ development and bone formation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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CD44v6 promotes ?-catenin and TGF-? expression, inducing aggression in ovarian cancer cells.
Wang J
Molecular Medicine Reports, 11(5), 3505-3510 (2015)
Ken Yoshida et al.
Stem cells translational medicine, 7(12), 893-905 (2018-10-01)
Serum used in culture medium brings risks of immune reactions or infections and thus may hinder using ex vivo expanded mesenchymal stem cells (MSCs) for medical treatment. Here, we cultured MSCs in a serum-free medium (SF-MSCs) and in a medium
Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes through the NF-?B signaling pathway in vivo and in vitro.
Wang Y
International Journal of Molecular Medicine, 35(4), 1067-1073 (2015)
Analysis of polymorphic TGFB1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults.
Stoll C
BMC Medical Genetics, 5:15, 1-9 (2004)
Loss-of-function of miR-142 by hypermethylation promotes TGF-?-mediated tumour growth and metastasis in hepatocellular carcinoma.
Yu Q
Cell Proliferation, 50(6) (2017)

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