SAB4503802

Anti-phospho-BTK (pTyr⁵⁵¹) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-AGMX1, Anti-AT, Anti-ATK, Anti-BPK, Anti-IGHD3, Anti-IMD1, Anti-PSCTK1, Anti-XLA
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 76 kDa
• species reactivity: rat, human, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; western blot: 1:500-1:1000
• NCBI accession no.: Q06187
• UniProt accession no.: Q06187
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr551)
• Gene Information: human ... BTK(695)

Description

General description

Bruton tyrosine kinase (BTK) is encoded by the gene mapped to human chromosome Xq22. The encoded protein belongs to the Tec family of kinases.

Immunogen

The antiserum was produced against synthesized peptide derived from human BTK around the phosphorylation site of Tyr551.

Immunogen Range: 516-565

Biochem/physiol Actions

Bruton tyrosine kinase (BTK) is a key element of B-cell–receptor signaling, which facilitates interactions with the tumor microenvironment and stimulates the survival and proliferation of chronic lymphocytic leukemia (CLL) cells. The encoded protein also plays a crucial role in activation of various constitutively active pathways of CLL-cell survival, such as the Akt, extracellular signal-regulated kinase (ERK) and nuclear factor κ light-chain enhancer of activated B cells (NF-κB) pathways. Additionally, it is also necessary for chemokine-mediated homing and adhesion of B cells. Polymorphisms in the gene are associated with the development of a symptomatic primary antibody deficiency (PAD), X-linked agammaglobulinemia.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable