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SAB4504557

Sigma-Aldrich

Anti-phospho-Tau (pSer396) antibody produced in rabbit

affinity isolated antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 78 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer396)

Gene Information

human ... MAPT(4137)

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This Item
SAB4504558SAB4504561SAB4504563
antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

technique(s)

ELISA: 1:20000, western blot: 1:500-1:1000

technique(s)

ELISA: 1:20000, western blot: 1:500-1:1000

technique(s)

ELISA: 1:20000, western blot: 1:500-1:1000

technique(s)

ELISA: 1:10000, western blot: 1:500-1:1000

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

UniProt accession no.

P10636

UniProt accession no.

P10636

UniProt accession no.

P10636

UniProt accession no.

P10636

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General description

MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. This gene is expressed in neurons but is most prominent in axons.

Immunogen

The antiserum was produced against synthesized peptide derived from human Tau around the phosphorylation site of Ser396.

Immunogen Range: 681-730

Application

Anti-phospho-Tau (pSer396) antibody has been used in the immunohistochemistry.

Biochem/physiol Actions

MAPT (microtubule associated protein tau) participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure. Removal of MAPT results in developmental delay and learning disability.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Proteomic analysis of mitochondria-enriched fraction isolated from the frontal cortex and hippocampus of apolipoprotein E knockout mice treated with Alda-1, an activator of mitochondrial aldehyde dehydrogenase (ALDH2).
Stachowicz A, et al.
International Journal of Molecular Sciences, 18(2), 435-435 (2017)
R Feio-Azevedo et al.
Archives of toxicology, 92(7), 2275-2295 (2018-06-06)
3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a widespread drug of abuse with known neurotoxic properties. The present study aimed to evaluate the differential toxic effects of MDMA in adolescent and aged Wistar rats, using doses pharmacologically comparable to humans. Adolescent (post-natal
Aneta Stachowicz et al.
International journal of molecular sciences, 18(2) (2017-02-22)
The role of different genotypes of apolipoprotein E (apoE) in the etiology of Alzheimer's disease is widely recognized. It has been shown that altered functioning of apoE may promote 4-hydroxynonenal modification of mitochondrial proteins, which may result in mitochondrial dysfunction
Kai Yao et al.
Drug design, development and therapy, 13, 387-396 (2019-02-06)
As a novel antidepressant drug, agomelatine has good therapeutic effect on the mood disorder and insomnia in Alzheimer's disease (AD). Recent studies have shown the neuroprotective function of agomelatine, including anti-oxidative and anti-apoptosis effect. However, it remains unclear whether agomelatine
Lizhen Cheng et al.
Cell communication and signaling : CCS, 21(1), 91-91 (2023-05-05)
Diabetic encephalopathy (DE) is a complication of type 2 diabetes mellitus (T2DM) that features Alzheimer's disease (AD)-like pathology, which can be degraded by the autophagy-lysosome pathway (ALP). Since transcription factor EB (TFEB) is a master regulator of ALP, TFEB-mediated ALP

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