SAB4702030

Monoclonal Anti-FOLR2 PE produced in mouse

• Synonym(s): BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, Folate receptor beta
• UNSPSC Code: 12352203

Properties

• conjugate: phycoerythrin (R-PE) conjugate
• Quality Level: 100
• antibody product type: primary antibodies
• clone: EM-35, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• concentration: 0.1 mg/ml
• technique(s): flow cytometry: suitable
• isotype: IgG1
• UniProt accession no.: P14207
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... FOLR2(2350)

Description

General description

FOLR2 (folate receptor beta) is a cell surface protein that was originally thought to be specific for placenta, but it can be also expressed in other tissues, including hematopoietic cells. Its expression is increased in malignant tissues. FOLR2 may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. FOLR2 is a marker for macrophages generated in the presence of M-CSF (M2), including M2-like tumor-associated macrophages, which exert potent immunosuppressive functions within the tumor environment, but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability.

Specificity

The mouse monoclonal antibody EM-35 recognizes an extracellular epitope on FOLR2, a 30-40 kDa cell surface protein serving as a receptor for folic acid.

Immunogen

BW5147alpha,beta- cells

Physical form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Storage and Stability

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable