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SAB5500023

Sigma-Aldrich

Anti-N-Cadherin, Rabbit monoclonal

clone SP90, recombinant, expressed in proprietary host, affinity isolated antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

SP90, monoclonal

species reactivity

human (tested)

species reactivity (predicted by homology)

mouse, bovine, rat

technique(s)

flow cytometry: 1:100
immunohistochemistry: 1:100

isotype

IgG

UniProt accession no.

application(s)

research pathology

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CDH2(1000)

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SAB5700640MABF3160MABT530
species reactivity

human (tested)

species reactivity

mouse, rat

species reactivity

hamster, human

species reactivity

rat, human

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

mouse

clone

SP90, monoclonal

clone

polyclonal

clone

8C11, monoclonal

clone

6A9.2, monoclonal

Gene Information

human ... CDH2(1000)

Gene Information

human ... CDH2(1000)

Gene Information

human ... CHD2(1000)

Gene Information

human ... CDH2(1000)

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

antibody form

purified antibody

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General description

N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of β-catenin. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Immunogen

Synthetic peptide corresponding to C-terminus of human cadherin-N protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Heping Lin et al.
Oncology letters, 16(2), 1809-1814 (2018-07-17)
The long noncoding RNA (lncRNA) colon cancer-associated transcript 1 (CCAT1) has been identified as an oncogene in multiple types of human malignancy, and the aberrant expression of CCAT1 has been associated with the tumorigenesis and progression of cancer. However, the

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