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SAB5500082

Sigma-Aldrich

Anti-Chromogranin A antibody, Rabbit monoclonal

clone SP12, recombinant, expressed in proprietary host, tissue culture supernatant

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NACRES:
NA.41

biological source

rabbit

Quality Level

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

SP12, monoclonal

species reactivity

human (tested)

species reactivity (predicted by homology)

bovine, pig

technique(s)

immunohistochemistry: 1:200

isotype

IgG

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CHGA(1113)

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biological source

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rabbit

conjugate

unconjugated

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conjugate

unconjugated

conjugate

unconjugated

clone

SP12, monoclonal

clone

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species reactivity

human (tested)

species reactivity

porcine, pig, monkey, rat, human, mouse

species reactivity

human (tested)

species reactivity

human (tested)

antibody form

tissue culture supernatant

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

tissue culture supernatant

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General description

Chromogranin A (CgA) is a circulating protein liberated by the neuroendocrine system. It is a glycoprotein that is located on human chromosome 14.
Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

Immunogen

Recombinant protein encoding human chromogranin A.

Biochem/physiol Actions

Chromogranin A (CgA) controls vascular physiology and angiogenesis. It modulates the storage and liberation of catecholamine via intracellular (vesiculogenic) and extracellular (catecholamine release–inhibitory) mechanisms. CHGA is essential to generate catecholamine secretory vesicles in chromaffin-lineage PC12 cells and is required to promote a regulated secretion system in nonsecretory cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Plasma levels of vasostatin-1, a chromogranin A fragment, are associated with carotid artery maximum stenosis: A pilot study.
Bachetti T, et al.
International Journal of Cardiology, 236, 438-443 (2017)
The human chromogranin A gene: chromosome assignment and RFLP analysis.
Modi WS, et al.
American Journal of Human Genetics, 45(5), 814-814 (1989)
Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology.
Wen G, et al.
American Journal of Human Genetics, 74(2), 197-207 (2004)

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