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SAB5500140

Sigma-Aldrich

Anti-MAGE-A1 antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP194, affinity isolated antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

SP194, monoclonal

species reactivity

human (tested)

technique(s)

flow cytometry: 1:400
immunoblotting: 1:400
immunohistochemistry: 1:100

isotype

IgG

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... MAGEA1(4100)

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This Item
SAB5500139M6320SAB5700891
species reactivity

human (tested)

species reactivity

human (tested)

species reactivity

human

species reactivity

mouse, human, rat

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

-

clone

SP194, monoclonal

clone

SP188, monoclonal

clone

MA454, monoclonal

clone

monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

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General description

Melanoma-associated antigen 1 (MAGE-A1) belongs to the melanoma-associated antigen (MAGE) gene family. It is also termed cancer-testis antigen (CTA) or cancer-germline (CG) gene. The MAGE-A1 gene is mostly expressed in the human germline. It is also expressed in the placenta and various tumor cells. MAGE-A1 gene is located on human chromosome Xq28.

Immunogen

Synthetic peptide derived from the C-terminus of human MAGE-A1 protein.

Biochem/physiol Actions

Melanoma-associated antigen 1 (MAGE-A1) stimulates the proliferation and colony formation of melanoma cells. It might modulate the oncogenic C-JUN expression either directly or via the extracellular-signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) signaling pathway. Hence, MAGE-A1 could be a possible therapeutic target for patients with melanoma. It can be a potential marker in the treatment of lung adenocarcinoma (LUAD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Dong Wang et al.
Biochemical and biophysical research communications, 473(4), 959-965 (2016-04-06)
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. Previous studies of MAGE-A1 in melanoma mainly focused on methylation changes or its
Yuan Mao et al.
Journal of hematology & oncology, 12(1), 106-106 (2019-10-24)
Cancer/testis antigens (CTAs) are a special type of tumor antigen and are believed to act as potential targets for cancer immunotherapy. In this study, we first screened a rational CTA MAGE-A1 for lung adenocarcinoma (LUAD) and explored the detailed characteristics

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