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SAB5701087

Sigma-Aldrich

Anti- HIF1α antibody produced in rabbit

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biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

polyclonal

form

liquid

species reactivity

mouse, human, rat

concentration

2.23 mg/mL

technique(s)

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HIF1A(3091)

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This Item
SAB5700707SAB5700842H6536
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

technique(s)

immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

technique(s)

western blot: 1:500-1:2000

technique(s)

western blot: 1:500-1:2000

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:1,000 using antigen retrieval, immunoprecipitation (IP): suitable, western blot: 1:500-1:1,000

species reactivity

mouse, human, rat

species reactivity

mouse, human, rat

species reactivity

human

species reactivity

rat, sheep, ferret, human, mouse

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

H1α67, monoclonal

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General description

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Immunogen

Recombinant protein of human HIF1α.

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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