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Key Documents

SCP0087

Sigma-Aldrich

Caspase 4 Inhibitor (ICH-2)

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C22H36N4O9
Molecular Weight:
500.54
UNSPSC Code:
12352200
NACRES:
NA.32

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Ac-Leu-Glu-Val-Asp-al

Application

Caspase 4 Inhibitor (Ac-LEVD-CHO) is used for the selective inhibition of caspase 4 to differentiate its role in specific cell apoptosis pathways.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Zong-Mei Bian et al.
Investigative ophthalmology & visual science, 50(12), 6006-6014 (2009-08-01)
To investigate the functional involvement of caspase-4 in human retinal pigment epithelial (hRPE) cells. Expression and activation of caspase-4 in hRPE cells were measured after stimulation with proinflammatory agents IL-1beta (2 ng/mL), TNF-alpha (20 ng/mL), lipopolysaccharide (1000 ng/mL), interferon-gamma (500
Akiko Yamamuro et al.
Journal of pharmacological sciences, 115(2), 239-243 (2011-02-02)
The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress-induced apoptosis in human neuronal cell line SH-SY5Y. Tunicamycin, which is known to induce ER stress, activated both caspase-9 and caspase-4, and the activation of caspase-4 preceded that

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