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SMB00580

Sigma-Aldrich

Vitamin K4

≥98% (HPLC)

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Synonym(s):
2-Methyl-1,4-naphthalenediol diacetate, Menadiol diacetate, Vitamin K diacetate, acetomenaphthone
Empirical Formula (Hill Notation):
C15H14O4
CAS Number:
Molecular Weight:
258.27
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.79

Quality Level

assay

≥98% (HPLC)

form

powder

technique(s)

HPLC: suitable

color

white to off-white

storage temp.

2-8°C

SMILES string

CC(OC1=CC(C)=C(OC(C)=O)C2=CC=CC=C21)=O

InChI

1S/C15H14O4/c1-9-8-14(18-10(2)16)12-6-4-5-7-13(12)15(9)19-11(3)17/h4-8H,1-3H3

InChI key

RYWSYCQQUDFMAU-UHFFFAOYSA-N

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1 of 4

This Item
70547095271H8017
vibrant-m

SMB00580

Vitamin K4

-
vibrant-m

95271

Vitamin K1

Premium Grade
vibrant-m

H8017

Hydroxocobalamin acetate

-
assay

≥98% (HPLC)

assay

97% (CP Sum of E & Z Isomers)

assay

≥99.0% (sum of isomers, HPLC)

assay

≥95% (HPLC)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

form

powder

form

liquid

form

viscous liquid

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

white to off-white

color

yellow to orange

color

light green-yellow to dark green-yellow, light yellow to dark yellow

color

red to brown

General description

Vitamin K4 (VK4), also referred to as 2-methyl-1,4-naphthalenediyldiacetate, is a synthetic hydrophilic form of vitamin K that belongs to menadione family. It is a diacetate form of VK3.

Biochem/physiol Actions

Vitamin K4 elicits anti-cancer functionality and induces apoptosis in prostate carcinoma.

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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T1503
Product Number
-
25G
Pack Size/Quantity

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway.
Jiang Y
Pharmazie, 68, 442-448 (2013)
One-Pot Hydroacetylation of Menadione (Vitamin K3) to Menadiol Diacetate (Vitamin K4) by Heterogeneous Catalysis.
Dobrinescu C
Advanced Synthesis & Catalysis, 354, 1301-1306 (2012)
Yu Jiang et al.
Die Pharmazie, 68(6), 442-448 (2013-07-24)
Vitamin K4 (VK4) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It has been reported that several vitamin Ks had inhibitory effects on various cancer cells. However, there is no report about VK4s anticancer activity.

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