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SML0036

Sigma-Aldrich

Procarbazine hydrochloride

≥98% (HPLC)

Synonym(s):

N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride

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25 EA
$73.30
100 EA
$226.00

$73.30

Available to ship onApril 01, 2025Details

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25 EA
$73.30
100 EA
$226.00

About This Item

Empirical Formula (Hill Notation):
C12H19N3O·HCl
CAS Number:
366-70-1
Molecular Weight:
257.76
EC Number:
206-678-6
MDL number:
MFCD00072082
UNSPSC Code:
12352200
PubChem Substance ID:
329825106
NACRES:
NA.77

$73.30

Available to ship onApril 01, 2025Details

Request a Bulk Order

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥18 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CNNCc1ccc(cc1)C(=O)NC(C)C

InChI

1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H

InChI key

DERJYEZSLHIUKF-UHFFFAOYSA-N

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suitability

suitable for (EIA/RIA; immunoassays)

suitability

suitable for (EIA/RIA; immunoassays)

suitability

suitable for (EIA/RIA; immunoassays)

suitability

suitable for (EIA/RIA; immunoassays)

material

clear bottom, flat bottom wells, round wells, clear wells, polystyrene

material

flat bottom clear , polystyrene , round wells

material

clear bottom, clear polystyrene , round bottom , round wells

material

flat bottom clear , polystyrene , round wells

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

feature

lid: no

feature

lid: no, skirt, plate format: 96 well standard, well: flat bottom, clear

feature

lid: no, skirt, plate format: 96 well standard

feature

lid: no, skirt, plate format: 96 well standard, well: flat bottom, clear

packaging

case of 100

packaging

pack of 1, case of 50, pkg of (individually wrapped)

packaging

case of 100, bag of 25

packaging

pack of 1, case of 100, pkg of (individually wrapped)

Application

Procarbazine hydrochloride has been used to study its physicochemical property.[1]
Procarbazine, an antineoplastic alkylating agent, may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an anticancer agent. It may be used to study new combination of anticancer drugs.

Biochem/physiol Actions

Procarbazine hydrochloride is a Antineoplastic alkylating agent
Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.
Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic.[2] Procarbazine is used in combination with therapy for treating Hodgkin′s disease.[3]

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
065M4741V
022M4745V
051M4739V

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