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SML0698

Sigma-Aldrich

CID 11210285 hydrochloride

≥98% (HPLC)

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Synonym(s):
2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine hydrochloride, AMBMP, N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride, Wnt Agonist
Empirical Formula (Hill Notation):
C19H18N4O3 · HCl
CAS Number:
Molecular Weight:
386.83
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)

InChI key

FABQUVYDAXWUQP-UHFFFAOYSA-N

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681664SML2179SML2425
vibrant-m

SML0698

CID 11210285 hydrochloride

vibrant-m

681664

Wnt Agonist I in DMSO

vibrant-m

SML2179

LDC000067 hydrochloride

vibrant-m

SML2425

Manidipine hydrochloride

form

powder

form

liquid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

solubility

DMSO: 20 mg/mL, clear

solubility

-

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear (warmed)

storage condition

desiccated

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage condition

protect from light

storage condition

desiccated

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

2-8°C

Application

CID 11210285 hydrochloride has been used as a Wnt agonist.

Biochem/physiol Actions

CID 11210285 is a cell-permeable, potent and selective activator of Wnt signaling without inhibiting GSK-3β. CID 11210285is a Wnt agonist.

Other Notes

Light sensitve and air sensitive.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD.
Cosin-Roger J, et al.
Mucosal Immunology, 9(4), 986-986 (2016)
Amalia Rosner et al.
Developmental biology, 448(2), 320-341 (2018-11-06)
Inhibitors of Apoptosis Protein (IAP) genes participate in processes like apoptosis, proliferation, innate immunity, inflammation, cell motility, differentiation and in malignancies. Here we reveal 25 IAP genes in the tunicate Botryllus schlosseri's genome and their functions in two developmental biology

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