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SML0737

Sigma-Aldrich

MitoTEMPO

≥98% (HPLC)

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Synonym(s):
(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride, Mito-TEMPO
Empirical Formula (Hill Notation):
C29H35N2O2P · Cl
CAS Number:
Molecular Weight:
510.03
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated
protect from light

color

white to light brown

solubility

H2O: 10 mg/mL, clear

storage temp.

−20°C

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This Item
487686176141588741
MitoTEMPO ≥98% (HPLC)

SML0737

MitoTEMPO

4-Hydroxy-TEMPO-d17 97 atom % D, 95% (CP)

487686

4-Hydroxy-TEMPO-d17

4-Hydroxy-TEMPO 95%

176141

4-Hydroxy-TEMPO

4-Amino-TEMPO-piperidinyl-d17 ≥98 atom % D, ≥98% (CP)

588741

4-Amino-TEMPO-piperidinyl-d17

assay

≥98% (HPLC)

assay

95% (CP)

assay

95%

assay

≥98% (CP)

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

H2O: 10 mg/mL, clear

solubility

-

solubility

-

solubility

-

storage condition

desiccated, protect from light

storage condition

-

storage condition

-

storage condition

-

Application

MitoTEMPO has been used as a mitochondria-targeted antioxidant.

Biochem/physiol Actions

MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide. MitoTEMPO is a combination of the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, giving MitoTEMPO the ability to pass through lipid bilayers with ease and accumulate several hundred-fold in mitochondria. Mitochondrial dysfunction and oxidative stress contribute to a variety of disorders involving cardiovascular, kidney, liver disorders, Parkinson′s and Alzheimer′s disease.

Other Notes

Light sensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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