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SML1402

Sigma-Aldrich

TCID

≥98% (HPLC)

Synonym(s):

4,5,6,7-Tetrachloro-1,3-indandione, 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione, CID 2729042, UCH-L3 Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C9H2Cl4O2
CAS Number:
30675-13-9
Molecular Weight:
283.92
MDL number:
MFCD00239209
UNSPSC Code:
12352200
PubChem Substance ID:
329825850
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1CC(C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C21)=O

InChI

1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2

InChI key

IDLAOWFFKWRNHB-UHFFFAOYSA-N

Biochem/physiol Actions

TCID is a cell penetrant potent and specific inhibitor of UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3). TCID is used to distinguish between UCH-L1 and UCH-L3 activities in cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anurag Rathore et al.
Scientific reports, 10(1), 5350-5350 (2020-03-27)
The major barrier to a HIV-1 cure is the persistence of latent genomes despite treatment with antiretrovirals. To investigate host factors which promote HIV-1 latency, we conducted a genome-wide functional knockout screen using CRISPR-Cas9 in a HIV-1 latency cell line

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