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SML1920

Sigma-Aldrich

ML364

≥98% (HPLC)

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Synonym(s):
2-(4-Methylphenylsulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide, 2-[[(4-Methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-benzamide
Empirical Formula (Hill Notation):
C24H18F3N3O3S2
CAS Number:
Molecular Weight:
517.54

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

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This Item
SML1348SML0638SML2274
Sigma-Aldrich

SML1920

ML364

STF-118804 ≥98% (HPLC)

SML1348

STF-118804

Sigma-Aldrich

SML0638

S0859

DDR1-IN-1 ≥98% (HPLC)

SML2274

DDR1-IN-1

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to light brown

color

white to beige

Biochem/physiol Actions

ML364 is a potent and specific inhibitor of the deubiquitinase USP2 that induces cellular Cyclin D1 degradation in HCT116 colorectal cancer cells, followed by cell cycle arrest and apoptosis. Also, ML364 inhibits homologous recombination (HR)-mediated DNA repair.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Mindy I Davis et al.
The Journal of biological chemistry, 291(47), 24628-24640 (2016-09-30)
Deubiquitinases are important components of the protein degradation regulatory network. We report the discovery of ML364, a small molecule inhibitor of the deubiquitinase USP2 and its use to interrogate the biology of USP2 and its putative substrate cyclin D1. ML364

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