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SML2307

Sigma-Aldrich

Lodoxamide

≥98% (HPLC)

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Synonym(s):
2,2′-[(2-Chloro-5-cyano-1,3-phenylene)diimino]bis-2-oxoacetic acid
Empirical Formula (Hill Notation):
C11H6ClN3O6
CAS Number:
Molecular Weight:
311.63
MDL number:

assay

≥98% (HPLC)

form

powder

color

white to very dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C11H6ClN3O6/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21)

InChI key

RVGLGHVJXCETIO-UHFFFAOYSA-N

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This Item
H9791SML0989SML2838
Lodoxamide ≥98% (HPLC)

SML2307

Lodoxamide

Hyp9

H9791

Hyp9

Sigma-Aldrich

SML0989

H2L5186303

AP20187 ≥98% (HPLC)

SML2838

AP20187

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >20 mg/mL

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to very dark brown

color

white to light yellow

color

white to beige

color

white to beige

Biochem/physiol Actions

Lodoxamide Tromethamine is a potent agonist of GPR35 in both human and rat, and an antiallergic mast cell stabilizer used clinically in the UK for treatment of allergic conjunctivitis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Soo-Jin Park et al.
British journal of pharmacology, 175(1), 154-161 (2017-10-27)
GPR35 has long been considered an orphan GPCR, because no endogenous ligand of GPR35 has been discovered. CXCL17 (a chemokine) has been reported to be an endogenous ligand of GPR35, and it has even been suggested that it be called
Alejandro Rodriguez-Garcia et al.
International ophthalmology, 38(3), 1243-1249 (2017-06-12)
To report the therapeutic efficacy and safety of topical 0.1% lodoxamide in the long-term treatment of superior limbic keratoconjunctivitis. Sixty-seven eyes of 34 patients with active SLK were studied. Therapeutic response was analyzed according to modified-Ohashi parameters. All eyes were
Amanda E MacKenzie et al.
Molecular pharmacology, 85(1), 91-104 (2013-10-12)
Lack of high potency agonists has restricted analysis of the G protein-coupled receptor GPR35. Moreover, marked variation in potency and/or affinity of current ligands between human and rodent orthologs of GPR35 has limited their productive use in rodent models of

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