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SML2466

Sigma-Aldrich

OXFBD04

≥98% (HPLC)

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Synonym(s):
3-(3,5-dimethylisoxazol-4-yl)-5-(hydroxy(pyridin-3-yl)methyl)phenol
Empirical Formula (Hill Notation):
C17H16N2O3
Molecular Weight:
296.32

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=NOC(C)=C1C2=CC(C(O)C3=CN=CC=C3)=CC(O)=C2

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This Item
SML0320SML1761SML1741
OXFBD04 ≥98% (HPLC)

SML2466

OXFBD04

FR180204 ≥98% (HPLC)

SML0320

FR180204

AA-CW236 ≥98% (HPLC)

SML1761

AA-CW236

TH1020 ≥95% (HPLC)

SML1741

TH1020

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 25 mg/mL protein, clear

solubility

DMSO: 3 mg/mL, clear (warmed)

color

white to beige

color

faintly yellow to dark yellow

color

white to beige

color

white to beige

Biochem/physiol Actions

OXFBD04 is a potent and selective inhibitor of BRD4(1) that inhibits interactions of BRD4with the RelA subunit of NF-κB. OXFBD02 inhibits proliferation of various cancer cell lines including leukaemia, breast, and renal cancer cell lines.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Laura E Jennings et al.
Bioorganic & medicinal chemistry, 26(11), 2937-2957 (2018-05-20)
Ligands for the bromodomain and extra-terminal domain (BET) family of bromodomains have shown promise as useful therapeutic agents for treating a range of cancers and inflammation. Here we report that our previously developed 3,5-dimethylisoxazole-based BET bromodomain ligand (OXFBD02) inhibits interactions

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