SML2466
OXFBD04
≥98% (HPLC)
Synonym(s):
3-(3,5-dimethylisoxazol-4-yl)-5-(hydroxy(pyridin-3-yl)methyl)phenol
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About This Item
Empirical Formula (Hill Notation):
C17H16N2O3
CAS Number:
Molecular Weight:
296.32
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=NOC(C)=C1C2=CC(C(O)C3=CN=CC=C3)=CC(O)=C2
Biochem/physiol Actions
OXFBD04 is a potent and selective inhibitor of BRD4(1) that inhibits interactions of BRD4with the RelA subunit of NF-κB. OXFBD02 inhibits proliferation of various cancer cell lines including leukaemia, breast, and renal cancer cell lines.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Laura E Jennings et al.
Bioorganic & medicinal chemistry, 26(11), 2937-2957 (2018-05-20)
Ligands for the bromodomain and extra-terminal domain (BET) family of bromodomains have shown promise as useful therapeutic agents for treating a range of cancers and inflammation. Here we report that our previously developed 3,5-dimethylisoxazole-based BET bromodomain ligand (OXFBD02) inhibits interactions
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