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SML2840

Sigma-Aldrich

AZD2066

≥98% (HPLC)

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Synonym(s):
4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine, AZD 2066
Empirical Formula (Hill Notation):
C19H16ClN5O2
CAS Number:
Molecular Weight:
381.82

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C19H16ClN5O2/c1-12(16-11-17(27-24-16)14-4-3-5-15(20)10-14)26-19-23-22-18(25(19)2)13-6-8-21-9-7-13/h3-12H,1-2H3/t12-/m1/s1

InChI key

SXWHYTICXCLKDG-GFCCVEGCSA-N

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This Item
SML1259SML1806PZ0402
Sigma-Aldrich

SML2840

AZD2066

GSK2194069 ≥97% (HPLC)

SML1259

GSK2194069

YU142670 ≥98% (HPLC)

SML1806

YU142670

PF-06807656 ≥98% (HPLC)

PZ0402

PF-06807656

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to light brown

color

white to light brown

color

white to beige

Biochem/physiol Actions

AZD2066 is an orally bioavailable, brain penetrant, selective and potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGlu5). AZD2066 exhibited satisfactory efficacy in patients suffering from neuropathic pain with mechanical hypersensitivity.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Matts Kågedal et al.
NeuroImage, 82, 160-169 (2013-05-15)
AZD2066 is a new chemical entity pharmacologically characterized as a selective, negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Antagonism of mGluR5 has been implicated in relation to various diseases such as anxiety, depression, and pain disorders.
Brittany A Jaso et al.
Current neuropharmacology, 15(1), 57-70 (2016-03-22)
Current pharmacotherapies for major depressive disorder (MDD) have a distinct lag of onset that can prolong distress and impairment for patients, and realworld effectiveness trials further suggest that antidepressant efficacy is limited in many patients. All currently approved antidepressant medications
Michael D B Swedberg et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 212-222 (2014-05-31)
The metabotropic glutamate receptor 5 (mGluR5) antagonists fenobam, MPEP (2-methyl-6-(phenylethynyl)pyridine), and MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine) were previously shown to not cause N-methyl-D-aspartate antagonist-like psychoactive effects in phencyclidine (PCP) drug discrimination studies, but to cause MTEP-like discrimination in rats, suggesting that the psychoactive

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