SML3128

HU-308

≥98% (HPLC)

• Synonym(s): (1S,4S,5S)-4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol, HU308
• Empirical Formula (Hill Notation): C₂₇H₄₂O₃
• CAS Number: 256934-39-1
• Molecular Weight: 414.62
• MDL number: MFCD23102377
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• optical activity: [α]/D 180.0 to 130.0°, c = 0.5 in chloroform-d
• storage condition: desiccated
• color: white to dark beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CCCCCCC(C)(C1=CC(OC)=C(C(OC)=C1)[C@]2(C=C([C@@H]3C(C)([C@H]2C3)C)CO)[H])C
• InChI: 1S/C27H42O3/c1-8-9-10-11-12-26(2,3)19-14-23(29-6)25(24(15-19)30-7)20-13-18(17-28)21-16-22(20)27(21,4)5/h13-15,20-22,28H,8-12,16-17H2,1-7H3/t20-,21+,22-/m0/s1
• InChI key: CFMRIVODIXTERW-BDTNDASRSA-N

Description

Biochem/physiol Actions

HU-308 is a potent, selective agonist of the cannabinoid receptor CB2. The Ki values for CB2 vs. CB1 are 22.7nM and >10 mM, respectively. HU-308 has anti-inflammatory and neuroprotective properties, and reduces liver damage in a hepatic ischemia/reperfusion injury model.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable