All Photos(1)
Synonym(s):
2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid, A 1155463
Empirical Formula (Hill Notation):
C35H32FN5O4S2
CAS Number:
Molecular Weight:
669.79
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C(C1=C(CN(C2=NC(C(O)=O)=C(CCCOC3=CC=C(C#CCN(C)C)C=C3F)S2)CC4)C4=CC=C1)NC5=NC6=C(S5)C=CC=C6
Biochem/physiol Actions
A-1155643 is a highly potent and highly selective BCLXL inhibitor that inhibits H146 small cell lung cancer xenograft tumor growth in mice.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Zhi-Fu Tao et al.
ACS medicinal chemistry letters, 5(10), 1088-1093 (2014-10-15)
A-1155463, a highly potent and selective BCL-XL inhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design. This compound is substantially more potent against BCL-XL-dependent cell lines relative to our recently reported inhibitor, WEHI-539, while possessing none
G Brent Dawe et al.
Nature communications, 10(1), 2746-2746 (2019-06-23)
Nicotinic acetylcholine receptors (nAChRs) mediate and modulate synaptic transmission throughout the brain, and contribute to learning, memory, and behavior. Dysregulation of α7-type nAChRs in neuropsychiatric as well as immunological and oncological diseases makes them attractive targets for pharmaceutical development. Recently
Anne Slomp et al.
Blood advances, 3(24), 4202-4214 (2019-12-20)
Prosurvival BCL-2 family proteins are potent inhibitors of apoptosis and often overexpressed in lymphoid malignancies. In multiple myeloma (MM), MCL-1 expression contributes to survival of malignant plasma cells, and overexpression correlates with poor prognosis. In this study, we investigated whether
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