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SML3609

Sigma-Aldrich

Sulthiame

≥95% (HPLC)

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Synonym(s):
4-(1,1-Dioxothiazinan-2-yl)benzenesulfonamide, 4-(Tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-benzenesulfonamide, 4-sulfamoyl-phenyl-[1,2]thiazinane-1,1-dioxide, Sultiame
Empirical Formula (Hill Notation):
C10H14N2O4S2
CAS Number:
Molecular Weight:
290.36
MDL number:

Quality Level

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

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T0909PZ0326PZ0343
Sulthiame ≥95% (HPLC)

SML3609

Sulthiame

Tenoxicam NSAID

T0909

Tenoxicam

Sigma-Aldrich

PZ0326

PF-03549184

PF-06260414 ≥98% (HPLC)

PZ0343

PF-06260414

assay

≥95% (HPLC)

assay

≥98% (perchloric acid titration)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

-10 to -25°C

storage temp.

-

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear

solubility

DMF: 25 mg/mL, clear, yellow-green

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

-

color

white to beige

color

light orange to dark orange

Biochem/physiol Actions

Sulthiame is a carbonic anhydrase (CA) inhibitor (hCA Ki in nM = 374/I, 7/II, 95/IV, 81/VA, 91/VB, 134/VI, 6/VII, 43/IX, 56/XII; Ki = 630 mM/hCA III, 1.45 μM/mCA XIII, 1.54 μM/hCA XIV) with anticonvulsant efficacy in vivo.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Claudia Temperini et al.
Bioorganic & medicinal chemistry letters, 17(17), 4866-4872 (2007-06-26)
Sulthiame, a clinically used antiepileptic, was investigated for its interaction with 12 catalytically active mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms. The drug is a potent inhibitor of CA II, VII, IX, and XII (K(I)s of 6-56 nM), and a
Tobias Leniger et al.
Epilepsia, 43(5), 469-474 (2002-05-25)
Sulthiame is a carbonic anhydrase (CA) inhibitor with an anticonvulsant effect in the treatment of benign and symptomatic focal epilepsy in children. The aim of the study was to elucidate the mode of action of sulthiame with respect to possible
Comparison of the Sulfonamide Inhibition Profiles of the ?- and ?-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei
Molecules (Basel), 22(3), 421-421 (2017)

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