SML3937

GPX4-Activator-1d4 Hydrochloride

≥98% (HPLC)

• Synonym(s): N-(2-Aminoethyl)-4-(3-cyclopentylthioureido)-benzenesulfonamide hydrochloride, N-(2-Aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide hydrochloride, PKUMDL-LC-101-D04
• Empirical Formula (Hill Notation): C₁₄H₂₂N₄O₂S₂·HCl
• CAS Number: 2143896-83-5
• Molecular Weight: 378.94
• MDL number: MFCD34676522
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: S=C(NC1=CC=C(C=C1)S(NCCN)(=O)=O)NC2CCCC2.Cl
• InChI key: FELDRJSFLBINQS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Cell penetrant, potent and elective allosteric activator of glutathione peroxidase 4 (GPX4) that potently inhibit ferroptosis.



GPX4-Activator-1d4 HCl is a cell penetrant, potent and elective allosteric activator of glutathione peroxidase 4 (GPX4) that potently inhibit ferroptosis. It significantly increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. GPX4-Activator-1d4 suppresses ferroptosis and inflammation in HT-1080 fibrosarcoma cells.

Caution

Hygroscopic

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable