SML3945
ARN11391
≥98% (HPLC)
Synonym(s):
2-Ethyl-N-[2-(oxan-2-ylmethoxy)phenyl]-4,5,6,7-tetrahydroindazole-3-carboxamide, ARN 11391, ARN-11391
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C22H29N3O3
CAS Number:
Molecular Weight:
383.48
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Selective inositol triphosphate receptor type 1 (ITPR1) potentiator for wild-type as well as two ITPR1 SCA29 mutants, R269W or T267M.
ARN11391 is a selective inositol triphosphate receptor type 1 (ITPR1), but not ITPR2 or ITPR3, potentiator (open channel probability (Po) = 0.2 with 20 µM ARN11391 and <0.01 without by on-nucleus nuclear patch-clamp using TPR1-YFP-expressing HEK293 cells) that potenitates IP3- (by photolysis of caged IP3) and UPT-induced calcium increase in HEK293 transfectants expressing wild-type as well as ITPR1 SCA29 mutants, R269W or T267M (5 µM UTP with or without 10 µM ARN11391).
ARN11391 is a selective inositol triphosphate receptor type 1 (ITPR1), but not ITPR2 or ITPR3, potentiator (open channel probability (Po) = 0.2 with 20 µM ARN11391 and <0.01 without by on-nucleus nuclear patch-clamp using TPR1-YFP-expressing HEK293 cells) that potenitates IP3- (by photolysis of caged IP3) and UPT-induced calcium increase in HEK293 transfectants expressing wild-type as well as ITPR1 SCA29 mutants, R269W or T267M (5 µM UTP with or without 10 µM ARN11391).
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Michele Genovese et al.
PNAS nexus, 2(1), pgac288-pgac288 (2023-01-31)
Pharmacological modulators of the Ca2+ signaling cascade are important research tools and may translate into novel therapeutic strategies for a series of human diseases. We carried out a screening of a maximally diverse chemical library using the Ca2+-sensitive Cl- channel
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service