SML4031

BAX Dimer Modulator 19, BDM19

≥98% (HPLC)

• Synonym(s): BDM-19, (E)-4-(6-Iodo-2-(3-methylstyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid, 4-[6-Iodo-2-[2-(3-methylphenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]benzoic acid, BDM 19, BDM19
• Empirical Formula (Hill Notation): C₂₄H₁₇IN₂O₃
• CAS Number: 500273-31-4
• Molecular Weight: 508.31
• MDL number: MFCD03302943
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: IC1=CC=C2C(C(N(C(/C=C/C3=CC(C)=CC=C3)=N2)C4=CC=C(C=C4)C(O)=O)=O)=C1

Description

Biochem/physiol Actions

Potent and selective cytosolic BAX dimer modulator that effectively induces apoptosis in cancer cells by selectively modulating inactive BAX.

BDM19, a potent BAX dimer modulator with a Kd of 560 nM, selectively binds to the N-terminal trigger site of inactive BAX, thereby inhibiting its dimerization with an IC50 of 5 μM. By stabilizing the inactive conformation of BAX, BDM-19 allosterically activates it, targeting cells containing cytosolic inactive BAX monomers and dimers. This leads to a dose-dependent translocation of BAX to mitochondria, subsequent cytochrome c release, and induction of apoptosis.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable