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Key Documents

SRP0351

Sigma-Aldrich

PDGFRb active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

Synonym(s):

CD140B, JTK12, platelet-derived growth factor receptor, beta polypeptide

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About This Item

CAS Number:
101463-26-7
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥70% (SDS-PAGE)

form

aqueous solution

mol wt

62 kDa

packaging

pkg of 10 μg

technique(s)

activity assay: suitable
inhibition assay: suitable

solubility

soluble
water: soluble

NCBI accession no.

NM_002609

UniProt accession no.

P09619

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PDGFRB(5159)

General description

Research area: Cell Cycle

Human PDGFRbeta (GenBank Accession No. NM_002609), cytoplasmic domain, amino acids 558-1106 (end) with N-terminal His-tag, MW= 62 kDa, expressed in Sf9 cells via a Baculovirus expression system.

Platelet-derived growth factor receptor (PDGFR) belongs to subclass III of receptor tyrosine kinases. The PDGFR exists as two isoforms, PDGFa and PDGFb-receptors, consisting of five extracellular immunoglobulin (Ig) loops and an intracellular tyrosine kinase (TK) domain.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biochem/physiol Actions

The PDGFβ receptor is involved in the development of the kidney, heart, placenta, blood vessels, and cardiovascular system. It also helps to regulate interstitial fluid pressure in tissues thus preventing edema. The activation of the PDGFβ receptor plays a crucial role in the process of wound healing. In addition to these functions, its overexpression is related to gastric cancer.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer
Liu B, et al.
Cancer Biomarkers : Section A of Disease Markers, 34(2), 251-264 (2022)
Drug targeting to myofibroblasts: Implications for fibrosis and cancer
Yazdani S, et al.
Advanced Drug Delivery Reviews, 121, 101-116 (2017)
The PDGF family: four gene products form five dimeric isoforms
Fredriksson, Linda and Li, Hong and Eriksson, Ulf
Cytokine & Growth Factor Reviews, 15(4) (2004)
C H Heldin et al.
Physiological reviews, 79(4), 1283-1316 (1999-10-03)
Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and heterodimers. The PDGF isoforms
L Claesson-Welsh et al.
Molecular and cellular biology, 8(8), 3476-3486 (1988-08-01)
The structure of the human receptor for platelet-derived growth factor (PDGF) has been deduced through cDNA cloning. A 5.45-kilobase-pair cDNA clone predicts a 1,106-amino-acid polypeptide, including the cleavable signal sequence. The overall amino acid sequence similarity with the murine PDGF

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