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Key Documents

SRP0476

Sigma-Aldrich

SMARCA2 (1375-1511) human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

BRM, SNF2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, SWI2, Sth1p

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

16.9 kDa

packaging

pkg of 100 μg

NCBI accession no.

NM_003070

UniProt accession no.

P51531

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SMARCA2(6595)

General description

Human Bromodomain SMARCA2 or BRM (GenBank Accession No. NM_003070) amino-acids 1375 – 1511 with N-terminal HIS-tag, MW = 16.9 kDa, expressed in an E. coli expression system.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Hunter Shain et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(5), E252-E259 (2012-01-12)
Defining the molecular genetic alterations underlying pancreatic cancer may provide unique therapeutic insight for this deadly disease. Toward this goal, we report here an integrative DNA microarray and sequencing-based analysis of pancreatic cancer genomes. Notable among the alterations newly identified
G Liu et al.
Oncogene, 30(29), 3295-3304 (2011-04-12)
SWI/SNF (SWItch/sucrose non-fermentable) complexes are ATP-dependent chromatin remodeling enzymes critically involved in the regulation of multiple functions, including gene expression, differentiation, development, DNA repair, cell adhesion and cell cycle control. BRM, a key SWI/SNF complex subunit, is silenced in 15-20%

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